The story of how one company triggered the worst drug epidemic in American history. Look into the epicenter of America's struggle with opioid addiction, from a distressed Virginia mining community, to the hallways of the DEA, and to the opulence of "one percenter" Big Pharma Manhattan.
Michael Keaton
Samuel Finnix
Peter Sarsgaard
Rick Mountcastle
Michael Stuhlbarg
Richard Sackler
Will Poulter
Billy Cutler
John Hoogenakker
Randy Ramseyer
Kaitlyn Dever
Betsy Mallum
Rosario Dawson
Bridget Meyer
Will Chase
Michael Friedman
Cleopatra Coleman
Grace Pell
Mare Winningham
Diane Mallum
Ian Unterman
Jonathan Sackler
Jake McDorman
John Brownlee
Phillipa Soo
Amber Collins
Brendan Patrick Connor
Howard Udell
Andrea Frankle
Beth Sackler
Arischa Conner
Leah Turner
Winsome Brown
Theresa Sackler
Andrés Erickson
Mortimer D.A. Sackler
Jaime Ray Newman
Kathe Sackler
Lawrence Arancio
Raymond Sackler
Raúl Esparza
Paul Mendelson
Ray McKinnon
Jerry Mallum
Deadra Moore
Karen Johnson
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Alayna Hester
Elizabeth Ann McClung
Rick Espaillat
Dr. Alan Spanos
Rebecca Wisocky
Cynthia McCormick
Carolee Carmello
Drea Price
Aaron Serotsky
David Haddox
Caitlin Mehner
Paula Greene
Nicholas Logan
Walt
Austin Freeman
Grant Simmons
Erin Dangler
Marianne Skolek
Paden Fallis
Louis Melton
Meagen Fay
Sister Beth Davies
Kenneth Tigar
Arthur Sackler
Helen Goldsby
Regina Carter
Annabelle Toomey
Catherine Brownlee
Andrea Powell
Sharon Burnham
Ryan Paynter
Teen
Amy Parrish
Judy Cohen
Adam Fristoe
James Comey
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Mark Jacoby
Dr. Hershel Jick
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Tricia Hawn
Shelly Finnix
Audrey Moore
Maureen Sara
Spencer Garrett
Larry Berger
Trevor Long
Rudy Giuliani
Amy Rutberg
Alice Fisher
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Susan Halsey Singer
Perdue Employee (uncredited)
Jody Matzer
Oak Valley Pharmacist
